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Walking speed as an aging biomarker in baboons (Papio hamadryas)
Hillary F Huber1, Kenneth G Gerow2, Peter W Nathanielsz1
1Department of Animal Sciences, Texas Pregnancy and Life-course Health Research Center, University of Wyoming, Laramie, WY, USA.
Background:
Walking speed is an important human aging biomarker. Baboons are valuable translational models for aging studies. Establishing whether walking speed is a good aging biomarker has value. We hypothesized there would be characteristic age-related decline in baboon walking speed.
Methods:
We studied 33 female baboons aged 5-21 years. Walking speed was calculated by the time to walk between landmarks separated by known distances. A regression model was developed to describe the relationship between speed, age, and body weight.
Results:
Speed negatively associated with age, a relationship enhanced by increased weight (P < 0.0005). For 16-kg animals, speed declined approximately 0.6 cm/s yearly. For each additional kilogram of weight, speed declined an additional 0.3 cm/s yearly.
Conclusions:
Baboon walking speed declines with age, an effect modulated by weight. Ease of measurement and strong age association make walking speed a valuable biomarker for aging research with this important experimental species.
