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Updated: Apr 2, 2026

Designing Porous Silicon Films as Carriers of Nerve Growth Factor
Published on: January 25, 2019
Nerve Growth Factor: A Focus on Neuroscience and Therapy
Luigi Aloe1, Maria Luisa Rocco, Bijorn Omar Balzamino
1Institute of Cell Biology and Neurobiology, National Research Council (CNR); NGF Section, Via Fosso di Fiorano, 64/65 - 00143 Rome, Italy. luigi.aloe@cnr.it.
Abstract:
Nerve growth factor (NGF) is the firstly discovered and best characterized neurotrophic factor, known to play a critical protective role in the development and survival of sympathetic, sensory and forebrain cholinergic neurons. NGF promotes neuritis outgrowth both in vivo and in vitro and nerve cell recovery after ischemic, surgical or chemical injuries. Recently, the therapeutic property of NGF has been demonstrated on human cutaneous and corneal ulcers, pressure ulcer, glaucoma, maculopathy and retinitis pigmentosa. NGF eye drops administration is well tolerated, with no detectable clinical evidence of systemic or local adverse effects. The aim of this review is to summarize these biological properties and the potential clinical development of NGF.
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