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Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Related Experiment Video

Updated: Apr 2, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
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Knee cartilage defect: marrow stimulating techniques.

M Zain Mirza1, Richard D Swenson2, Scott A Lynch3

  • 1Penn State Hershey Bone and Joint Institute, 30 Hope Drive, Building B, Suite 2400, Hershey, PA, 17033-0850, USA. mmirza@hmc.psu.edu.

Current Reviews in Musculoskeletal Medicine
|September 29, 2015
PubMed
Summary

Chondral defects in the knee are challenging. This review examines current marrow stimulating techniques for knee cartilage restoration, exploring advancements in stem cell biology and biotechnology.

Keywords:
Bone marrow stimulationMarrow stimulating techniquesMicrofractureOsteochondral lesionPlatelet-rich plasmaScaffolding

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Related Experiment Videos

Last Updated: Apr 2, 2026

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Area of Science:

  • Orthopedics
  • Sports Medicine
  • Regenerative Medicine

Background:

  • Painful chondral defects of the knee present significant clinical challenges.
  • The incidence of knee chondral lesions is variable and often asymptomatic.
  • Current cartilage restoration methods include marrow stimulation, grafts, and cell transplantation.

Purpose of the Study:

  • To review current marrow stimulating techniques for knee chondral damage.
  • To explore advancements in stem cell biology and biotechnology for cartilage repair.

Main Methods:

  • Literature review of current techniques in cartilage restoration.
  • Focus on marrow stimulating techniques and their biological enhancements.
  • Exploration of stem cell and biotechnology applications.

Main Results:

  • Marrow stimulating techniques aim to enhance and guide the biology of microfracture.
  • Stem cell biology and biotechnology offer new avenues for cartilage repair research.
  • Variable rates of chondral lesions are reported during arthroscopic examinations.

Conclusions:

  • Marrow stimulating techniques are evolving with advancements in regenerative medicine.
  • Further research into stem cell applications holds promise for knee cartilage restoration.
  • Understanding chondral defect biology is crucial for effective treatment strategies.