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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Risk factors associated with preterm birth after a prior term delivery.

L F Wong1,2, J Wilkes3,4, K Korgenski3,4

  • 1Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA. luchin.wong@gmail.com.

BJOG : an International Journal of Obstetrics and Gynaecology
|September 29, 2015
PubMed
Summary
This summary is machine-generated.

First-time mothers who have a cesarean delivery, start smoking, or have a short interpregnancy interval (<18 months) face increased risks for preterm birth in subsequent pregnancies. Postpartum counseling is recommended for tobacco cessation and appropriate interpregnancy spacing.

Keywords:
Caesarean deliveryintrapartumpreterm birthtobacco

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Area of Science:

  • Reproductive Health
  • Maternal-Fetal Medicine
  • Obstetrics

Background:

  • Preterm birth (PTB) is a leading cause of neonatal morbidity and mortality.
  • Identifying modifiable risk factors for PTB is crucial for developing effective prevention strategies.
  • Primiparous women with no prior history of PTB may acquire new risk factors in subsequent pregnancies.

Purpose of the Study:

  • To investigate newly acquired risk factors for preterm birth (PTB) in women with no prior history of PTB.
  • To identify factors associated with the term-preterm sequence in first-time mothers.

Main Methods:

  • A case-control study was conducted using delivery data from 2002 to 2012 within a large healthcare system.
  • Women with a term birth followed by a preterm birth (term-preterm cases) were compared to women with two term births (term-term controls).
  • Social factors and intrapartum labor characteristics from the first pregnancy were analyzed between cases and controls.

Main Results:

  • The study included 38,215 women, with 1353 (3.8%) identified as term-preterm cases.
  • Cesarean delivery in the first pregnancy (aOR=2.20), new tobacco use (aOR=2.33), and interpregnancy interval <18 months (aOR=1.37) were significantly associated with the term-preterm sequence.
  • Maternal age and race/ethnicity did not differ significantly between cases and controls.

Conclusions:

  • Cesarean delivery during the first pregnancy, initiation of tobacco use, and a short interpregnancy interval (<18 months) are significant risk factors for the term-preterm sequence.
  • Postpartum counseling on appropriate interpregnancy intervals and smoking cessation is recommended for women.
  • These findings highlight critical periods for intervention to reduce subsequent preterm birth risk.