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Related Experiment Video

Updated: Apr 2, 2026

Author Spotlight: Investigating the Impact of Aging on Hippocampal-Dependent Spatial Learning
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Mente Activa® Improves Impaired Spatial Memory in Aging Rats.

M D López-Avalos1, R Fernández-Llebrez Zayas, M Cifuentes

  • 1C. Pedraza, Dpto. Psicobiología y Metodología de las CC. Facultad de Psicología. Universidad de Málaga, Campus de Teatinos s/n., Málaga, 29071. Spain, Tel: +34 952 132 510; Fax: +34 952 134 142,

The Journal of Nutrition, Health & Aging
|September 29, 2015
PubMed
Summary
This summary is machine-generated.

Mente Activa® supplementation improved spatial memory and learning in aged rats without causing adverse effects. This suggests its potential for combating age-related cognitive decline.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Nutritional Science

Background:

  • Cognitive decline is a common aspect of aging, impacting individuals and society.
  • Dietary supplements show promise in mitigating age-related cognitive impairments.

Purpose of the Study:

  • To evaluate the efficacy of Mente Activa® in addressing age-related cognitive deficits.
  • To assess the safety profile of Mente Activa® in aged rats.

Main Methods:

  • Aged rats (n=60) were administered Mente Activa® or a placebo for 5 months.
  • Spatial learning and memory were assessed using the Morris water maze pre- and post-intervention.
  • Plasma parameters, heart anatomy, and liver function were monitored for side effects.

Main Results:

  • Mente Activa® treated rats exhibited enhanced spatial memory, evidenced by reduced escape latency and swimming distance.
  • Supplemented rats demonstrated improved learning strategies and memory recall compared to controls.
  • No adverse effects were observed in plasma parameters or heart size in the Mente Activa® group.

Conclusions:

  • Sustained Mente Activa® intake significantly improved learning and memory in aged rats.
  • Mente Activa® demonstrates therapeutic potential and safety for managing age-related cognitive deficits.
  • Early intervention with Mente Activa® may be beneficial at the onset of cognitive dysfunction symptoms.