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Atrial Electromechanical Properties in Coeliac Disease
Tolga Han Efe1, Ahmet Goktug Ertem2, Yusuf Coskun3
1Department of Cardiology, Diskapi Education and Training Hospital, Ankara, Turkey.
Heart, Lung & Circulation
|September 29, 2015
Summary
Patients with coeliac disease (CD) show prolonged atrial electromechanical delay (EMD), an early marker for atrial fibrillation (AF). This suggests EMD may help predict AF risk in individuals with CD.
Area of Science:
- Cardiology
- Gastroenterology
- Immunology
Background:
- Coeliac disease (CD) is an autoimmune disorder linked to inflammation.
- Inflammation is associated with atrial fibrillation (AF) development.
- Atrial electromechanical delay (EMD) is a potential early marker for AF.
Purpose of the Study:
- To evaluate atrial electromechanical properties in CD patients.
- To compare EMD in CD patients versus healthy controls.
Main Methods:
- 39 CD patients and 26 healthy volunteers were studied.
- Transthoracic echocardiography and ECG were used to measure EMD.
- Interatrial, left intraatrial, and right intratrial EMD were calculated.
Main Results:
- CD patients had significantly prolonged left and right intraatrial EMDs and interatrial EMD compared to controls.
- Interatrial EMD correlated with age, disease duration, and CD biomarkers.
- Disease duration, anti-endomysium antibodies, and disease status independently predicted interatrial EMD.
Conclusions:
- Atrial EMD parameters are significantly elevated in CD patients.
- Atrial EMD measurement may predict AF risk in coeliac disease.
