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Microparticle and Atherothrombotic Diseases

Shosaku Nomura1

  • 1First Department of Internal Medicine, Kansai Medical University.

Journal of Atherosclerosis and Thrombosis
|September 29, 2015
PubMed

Insights

Microparticles (MPs), small vesicles from cells, are linked to thrombotic diseases. Elevated MPs may serve as a valuable biomarker for identifying atherothrombosis.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Pathophysiology

Background:

  • Microparticles (MPs) are cell-derived membrane vesicles released during activation or apoptosis.
  • MPs express phospholipids, contributing to procoagulant activity.
  • Elevated levels of MPs from platelets, endothelial cells, and monocytes are common in thrombotic diseases.

Purpose of the Study:

  • To review the multifaceted roles of MPs beyond their procoagulant activity.
  • To explore the diagnostic potential of MPs in various clinical disorders.
  • To assess the utility of MPs as biomarkers for atherothrombosis.

Main Methods:

  • Literature review of studies on microparticle origin, composition, and function.
  • Analysis of data linking circulating MP levels to thrombotic diseases.
  • Evaluation of evidence for MP involvement in clinical disorders.

Main Results:

  • MPs exhibit diverse functions beyond procoagulant activity.
  • Circulating MP levels vary based on disease type, state, and treatment.
  • Increased MPs are implicated in numerous clinical disorders.

Conclusions:

  • Microparticles have expanded roles in physiology and pathology.
  • MPs show promise as diagnostic and prognostic biomarkers.
  • Evidence suggests MPs are useful biomarkers for identifying atherothrombosis.

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