Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quantitative VEP analysis in children with cortical visual impairment.

R Bencivenga1, P K Wong, S Woo

  • 1Department of Diagnostic Neurophysiology, B.C.'s Children's Hospital, Vancouver, Canada.

Brain Topography
|January 1, 1989
PubMed
Summary

New electrophysiologic measures derived from visual evoked potentials (VEP) can help diagnose cortical visual impairment (CVI) in children. Specific VEP-based "R values" show promise as objective diagnostic tools, particularly for children over five.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reproducibility of radiomic features of the brain on ultrahigh-field MRI at 7 Tesla: a comparison of different segmentation techniques.

Clinical radiology·2025
Same author

Strengthening service integration of non-locally trained healthcare professionals through crew resource management: longitudinal measures and beyond.

Hong Kong medical journal = Xianggang yi xue za zhi·2025
Same author

Assisted reproductive techniques and subsequent risk of asthma and allergic rhinitis in offspring: a nationwide birth cohort study in South Korea.

European review for medical and pharmacological sciences·2024
Same author

Surgery for maxillary oral squamous cell carcinoma: the effect of surgical resection margins and elective neck dissection on oncological outcomes.

International journal of oral and maxillofacial surgery·2022
Same author

Molecular insights into the development of hepatic metastases in colorectal cancer: a metastasis prediction study.

European review for medical and pharmacological sciences·2020
Same author

Nanoscale heat transport through the hetero-interface of SrRuO<sub>3</sub> thin films.

Nanotechnology·2019

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Biomedical Engineering

Background:

  • Cortical visual impairment (CVI) in children often presents typically, but objective electrophysiologic confirmation can be valuable.
  • Existing diagnostic methods for CVI may benefit from supplementary objective measures.

Purpose of the Study:

  • To investigate the utility of mathematically derived parameters from visual evoked potentials (VEP) for diagnosing CVI in children.
  • To identify specific VEP-based metrics that can differentiate CVI patients from healthy controls.

Main Methods:

  • Utilized 20-channel visual evoked potential (VEP) recordings from 30 children with CVI and 52 controls.
  • Applied Hjorth's source derivation to VEP data to minimize reference contamination and enhance signal localization.

Related Experiment Videos

  • Calculated 'R values,' representing ratios of electrophysiologic activity between different electrode areas, as potential diagnostic markers.

    • Main Results:

    • Several 'R values' demonstrated significant separation between CVI patients and control groups, especially in children older than 5 years.
    • A low occipital-to-parietal activity ratio was a key indicator in CVI patients.
    • The derived 'R values' showed age independence in the normal population and were easily computed.

    Conclusions:

    • Mathematically derived 'R values' from VEP offer a promising, objective method for confirming CVI diagnoses in children.
    • The occipital-to-parietal activity ratio is a particularly sensitive VEP-based parameter for CVI detection.
    • These findings suggest 'R values' can serve as valuable confirmatory diagnostic measures for pediatric CVI.