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Updated: Apr 2, 2026

In Vivo Two-photon Imaging of Megakaryocytes and Proplatelets in the Mouse Skull Bone Marrow
Published on: July 28, 2021
[Bone Cell Biology Assessed by Microscopic Approach. An application of two-photon microscopy for histopathological
1Division of Analytical Bio-Medicine, Advanced Research Support Center (ADRES), Ehime University, Japan./Division of Bio-Imaging, Proteo-Science Center (PROS), Ehime University, Japan./Translational Research Center and Artificial Joint Integrated Center, Ehime University Hospital, Japan.
Abstract:
Histopathological analysis has long been a gold standard in bio-medical research and clinical medicine. However, it is hard to quantitatively demonstrate histopathological difference. In this review, I will briefly describe principals of two-photon microscopy, and then introduce an application of second harmonic generation-based imaging for quantitative histopathological analysis of cartilage and bone.
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