Apelin Levels In Isolated Coronary Artery Ectasia

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Mehmet Zihni Bilik1, İbrahim Kaplan2, Abdulkadir Yıldız1

  • 1Department of Cardiology, Medicine Faculty, Dicle University, Diyarbakır, Turkey.

Korean Circulation Journal
|September 29, 2015
PubMed

Insights

Plasma apelin levels are significantly lower in patients with isolated coronary artery ectasia (CAE). This study identified a novel relationship between apelin and CAE, suggesting a potential role in its nonatherosclerotic mechanism.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • The exact causes of coronary artery ectasia (CAE) remain unclear.
  • While often linked to atherosclerosis, isolated CAE involves nonatherosclerotic pathways.
  • Previous research explored apelin's role in atherosclerotic coronary artery disease, but its function in isolated CAE was unexamined.

Purpose of the Study:

  • To investigate the relationship between plasma apelin levels and isolated coronary artery ectasia (CAE).
  • To determine if apelin levels differ between patients with isolated CAE and healthy controls.

Main Methods:

  • A total of 54 participants were included: 26 with isolated CAE and 28 healthy controls.
  • Demographic and risk factor profiles were similar between groups.
  • Plasma apelin levels were quantified using an enzyme-linked immunoassay kit.

Main Results:

  • Patients with isolated CAE exhibited significantly lower plasma apelin levels (0.181±0.159 ng/mL) compared to the control group (0.646±0.578 ng/mL).
  • The difference in apelin levels between the groups was statistically significant (p=0.033).
  • No significant differences were observed in glucose, creatinine, total cholesterol, triglyceride, LDL-C, or HDL-C levels between the groups.

Conclusions:

  • This study demonstrates that individuals with isolated coronary artery ectasia have reduced plasma apelin levels.
  • A significant association between plasma apelin and isolated CAE was established.
  • These findings suggest apelin may play a role in the pathogenesis of isolated CAE.
Abstract

Keywords:
Apelin protein, humanCoronary artery diseaseDilatation, pathologicInflammation

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