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Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
Renal failure in cirrhosis: Emerging concepts
Paulo Lisboa Bittencourt1, Alberto Queiroz Farias1, Carlos Terra1
1Paulo Lisboa Bittencourt, Unit of Gastroenterology and Hepatology, Portuguese Hospital, Salvador, BA 40140-901, Brazil.
Abstract:
Acute renal failure, now termed acute kidney injury (AKI), is frequently found in patients with cirrhosis. The occurrence of AKI, irrespective of the underlying cause, is associated with reduced in-hospital, 3-mo and 1-year survival. Hepatorenal syndrome is associated with the worst outcome among AKI patients with cirrhosis. Several definitions for AKI that have been proposed are outlined and evaluated in this paper. Among these, the International Club for Ascites-AKI criteria substantially strengthen the quality of early diagnosis and intervention according to underlying cause of AKI.
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