Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

980
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
980
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

1.2K
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
1.2K
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

1.9K
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
1.9K
Renal Corpuscle01:20

Renal Corpuscle

9.1K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
9.1K
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

664
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
664
Nephrons01:10

Nephrons

9.0K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
9.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of Inflammatory Markers as Predictors of Response to Antidepressants in Major Depressive Disorder: A Meta-Analysis.

Cureus·2026
Same author

Rapid Reduction in Proteinuria With the Initiation of Voclosporin in Lupus Nephritis: A Single-Center Experience.

Cureus·2026
Same author

Association between interstitial fibrosis/tubular atrophy (IFTA) on kidney biopsies and anti Ro60 antibody positivity in patients with lupus nephritis (LN).

Lupus·2026
Same author

GLP-1 Receptor Agonists in the Management of Post-bariatric Weight Regain and Dysglycemia: A Systematic Review and Meta-Analysis.

Cureus·2026
Same author

Ferritin as a predictive salivary marker for ECC-III.

Bioinformation·2026
Same author

Assimilation of high-resolution Ocean Color Monitor (OCM) aerosol optical depth in WRF-Chem improves PMâ‚‚.â‚… forecasts over the Indian region.

Scientific reports·2025

Related Experiment Video

Updated: Apr 2, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.6K

Granulomatous interstitial nephritis.

Shivani Shah1, Naima Carter-Monroe1, Mohamed G Atta1

  • 1Johns Hopkins University , Baltimore, MD , USA.

Clinical Kidney Journal
|September 29, 2015
PubMed
Summary

Granulomatous interstitial nephritis (GIN), a rare kidney condition, can be triggered by medications like antibiotics. Early diagnosis via renal biopsy and treatment with corticosteroids can improve kidney function.

Area of Science:

  • Nephrology
  • Pathology

Background:

  • Granulomatous interstitial nephritis (GIN) is a rare renal pathology, affecting 0.5-0.9% of renal biopsies.
  • GIN is associated with various medications (antibiotics, NSAIDs) and granulomatous disorders (sarcoidosis, infections).

Purpose of the Study:

  • To review the clinical associations, presentation, diagnosis, and treatment of GIN.
  • To highlight a case of GIN attributed to doxycycline.

Main Methods:

  • Literature review of GIN associations and treatments.
  • Case report detailing patient presentation, urinalysis, and renal biopsy findings.

Main Results:

  • The patient presented with acute kidney injury, confusion, rash, pyuria, and eosinophiluria.
Keywords:
AINAKIdoxycyclinegranuloma

More Related Videos

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
04:37

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

1.8K
An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

14.8K

Related Experiment Videos

Last Updated: Apr 2, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.6K
Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
04:37

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

1.8K
An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

14.8K
  • Renal biopsy confirmed acute interstitial nephritis with granulomas, linked to doxycycline therapy.

    • Conclusions:

    • GIN is an uncommon cause of acute kidney injury, often treatable by removing the offending agent and corticosteroid therapy.
    • Prompt diagnosis through renal biopsy is crucial for managing GIN and improving renal outcomes.