Related Experiment Video
Updated: Apr 2, 2026
Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
Published on: June 13, 2025
Albuminuria, renal dysfunction and circadian blood pressure rhythm in older men: a population-based longitudinal
Hong Xu1, Xiaoyan Huang2, Ulf Risérus3
1Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology , Karolinska Institutet , Stockholm , Sweden.
Insights
Albuminuria and kidney dysfunction impact blood pressure rhythm in older men. Kidney dysfunction worsens these effects, increasing the risk of non-dipper blood pressure patterns.
Area of Science:
- Nephrology
- Cardiology
- Gerontology
Background:
- Circadian blood pressure (BP) rhythm is crucial for cardiovascular health.
- Albuminuria and kidney dysfunction are known risk factors for cardiovascular disease.
- The interplay between albuminuria, kidney dysfunction, and BP rhythm is not fully understood.
Purpose of the Study:
- To investigate the association between albuminuria and kidney dysfunction with circadian BP rhythm.
- To examine the interaction of these factors on BP rhythm variation.
- To assess their impact on the progression of the non-dipper BP pattern in older men.
Main Methods:
- Cross-sectional and longitudinal analyses of the Uppsala Longitudinal Study of Adult Men.
- Inclusion of 1051 men (age 71) with measurements of urinary albumin excretion rate (UAER), 24-h ambulatory BP monitoring (ABPM), and cystatin-C-estimated glomerular filtration rate (eGFR).
- Follow-up examination of 574 men after 6 years to assess changes in ABPM and non-dipper BP patterns.
Main Results:
- Albuminuria was associated with circadian BP rhythm changes both cross-sectionally and longitudinally.
- Significant interactions between UAER and kidney dysfunction (eGFR < 60 mL/min/1.73 m²) were found in relation to night-time SBP and night-day SBP ratio.
- High UAER independently predicted non-dipper BP progression, with a stronger effect observed in men with concurrent kidney dysfunction.
Conclusions:
- Albuminuria is linked to altered circadian BP rhythm and non-dipper pattern progression in elderly men.
- Concurrent kidney dysfunction significantly modifies and exacerbates these associations.
- These findings highlight the importance of monitoring renal function in relation to BP regulation in older populations.
Background:
Both albuminuria and kidney dysfunction may affect circadian blood pressure (BP) rhythm, while exacerbating each other's effects. We investigated associations and interactions of these two risk factors with circadian BP rhythm variation and non-dipper pattern progression in community-dwelling older men.
Methods:
This was a cross-sectional and longitudinal analyses in the third and fourth cycles of the Uppsala Longitudinal Study of Adult Men, including 1051 men (age 71 years) with assessments on urinary albumin excretion rate (UAER), 24-h ambulatory BP monitoring (ABPM) and cystatin-C-estimated glomerular filtration rate (eGFR). Of these, 574 men attended re-examination after 6 years. Study outcomes were ABMP changes and non-dipping BP pattern (prevalence and progression).
Results:
UAER associated with circadian BP rhythm both cross-sectionally and longitudinally. Longitudinally, significant interactions were observed between UAER and kidney dysfunction (eGFR < 60 mL/min/1.73 m(2)) in its association with the changes of both night-time systolic BP (SBP) and night-day SBP ratio. After stratification, UAER strongly predicted night-day SBP ratio change only in those with concurrent kidney dysfunction. At re-examination, 221 new cases of non-dipper were identified. In multivariable logistic models, high UAER associated with increased likelihood of non-dipper progression, but more strongly so among individuals with concurrent kidney dysfunction. These associations were evident also in the subpopulation of non-diabetics and in participants with normal range UAER.
Conclusions:
UAER associates with circadian BP rhythm variation and non-dipper progression in elderly men. Concurrent renal dysfunction modifies and exacerbates these associations.
Related Concept Videos
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
01:28Factors affecting Blood pressure
Physiological Factors:
01:18Hypertension and Regulation of Blood Pressure