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Updated: Apr 2, 2026
Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
Published on: November 13, 2016
Oral glucose tolerance testing to modulate plasma amyloid levels: A novel biomarker
Esther S Oh1, Christopher M Marano2, Jeannie-Marie Leoutsakos3
1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Introduction:
Plasma levels of amyloid-beta (Aβ) do not correlate well with different stages of Alzheimer's disease (AD) in cross-sectional studies. Measuring the changes in Aβ plasma levels with an acute intervention may be more sensitive to distinguishing individuals in earlier stages of AD (mild cognitive impairment; MCI) from normal controls.
Methods:
57 participants (18 with AD/MCI and 39 cognitively normal controls) underwent oral glucose tolerance testing (OGTT). Blood samples were obtained over a 2 hour time period. Changes in plasma Aβ40 and42 levels were measured from either baseline or 5 minutes to the 10 minute time point.
Results:
Compared to normal controls, subjects with AD/MCI had significantly less change (Δ) in plasma levels for both Aβ40(-3.13(40.93)pg/ml vs. 41.34(57.16)pg/ml;p=0.002) and Aβ42(-0.15(3.77)pg/ml vs. 5.64(10.65)pg/ml; p=0.004).
Discussion:
OGTT combined with measures of plasma Aβ40 and 42 is potentially useful in distinguishing aging individuals who are in different stages of AD.
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