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Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
Published on: March 9, 2017
Electronic communication of cells with a surface mediated by boronic acid saccharide interactions
Alex Stephenson-Brown1, Sue Yong2, Muhammad H Mansor2
1School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, UK.
Abstract:
The fabrication of a molecularly tailored surface functionalised with a saccharide binding motif, a phenyl boronic acid derivative is reported. The functionalised surface facilitated the transfer of electrons, via unique electronic interactions mediated by the presence of the boronic acid, from a macrophage cell line. This is the first example of eukaryotic cellular-electrical communication mediated by the binding of cells via their cell-surface saccharide units.
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