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The in vitro effect of methylmercuric chloride on superoxide dismutase activity of pig platelets
B Kostka1, U Krajewska, K Lipecka
1Department of Biochemistry, Medical Academy, Lódź, Poland.
Polish Journal of Pharmacology and Pharmacy
|September 1, 1989
Abstract:
Incubation of the suspension of washed pig platelets with methylmercuric chloride (MeHg) caused decrease of superoxide dismutase (SOD) activity at the concentrations of MeHg 10(-5)-10(-4) mol/l. We also observed the increase of enzyme activity at low concentrations of MeHg (10(-7)-10(-6) mol/l). MeHg affects the SOD activity similarly to other mercurials which are known to react with sulfhydryl groups, and differentially influence enzymatic systems.