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Children's Interstitial and Diffuse Lung Disease. Progress and Future Horizons

Robin R Deterding1

  • 1Department of Pediatrics, Pulmonary Medicine Section, University of Colorado, Denver, Colorado; and Breathing Institute, Children's Hospital Colorado, Aurora, Colorado.

Annals of the American Thoracic Society
|September 29, 2015
PubMed

Insights

Significant progress has been made in understanding and treating children's interstitial and diffuse lung disease (chILD). Future research and global collaboration promise new treatments for these rare pediatric lung disorders.

Area of Science:

  • Pediatric Pulmonology
  • Rare Diseases
  • Genetics

Background:

  • Children's interstitial and diffuse lung disease (chILD) comprises a diverse group of rare, severe pediatric lung disorders.
  • Recent decades show marked advancements in chILD classification, care, and research infrastructure.

Purpose of the Study:

  • To review historical developments in chILD.
  • To highlight major clinical and research updates in chILD.
  • To discuss future opportunities for chILD research and treatment.

Main Methods:

  • Review of historical data and recent literature on chILD.
  • Analysis of progress in disease classification and genetic definitions.
  • Examination of organizational structures and collaborative efforts in chILD research.

Main Results:

  • New chILD diseases have been identified and genetically defined.
  • Classification systems have been developed and implemented.
  • Dedicated organizations (chILDRN, chILD Foundation) and global collaborations have been established.

Conclusions:

  • Substantial progress has enhanced the care of children with chILD.
  • Future prospects include expanded scientific discovery and broader collaborations.
  • The outlook is promising for developing novel treatments for these rare pediatric lung diseases.

Keywords:
childrendiffuse lung diseaseinterstitial lung disease

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