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Published on: September 12, 2025
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Uterine artery embolization using progressively larger calibrated gelatin sponge particles
Yun Gyu Song1, Young Ju Woo2, Chang-Woon Kim2
1a Department of Radiology , Samsung Changwon Hospital, Sungkyunkwan University School of Medicine , Changwon , Korea.
Summary
Uterine artery embolization (UAE) with larger gelatin sponge particles effectively reduces uterine fibroid volume and symptoms. This safe procedure significantly improves quality of life for women with symptomatic fibroids.
Area of Science:
- Interventional Radiology
- Gynecologic Surgery
- Vascular Interventions
Background:
- Symptomatic uterine fibroids significantly impact women's health and quality of life.
- Uterine artery embolization (UAE) is a minimally invasive treatment option for uterine fibroids.
- Optimizing embolic agents and techniques is crucial for improving UAE outcomes.
Purpose of the Study:
- To evaluate the efficacy and safety of UAE using progressively larger calibrated gelatin sponge particles.
- To assess the impact of this UAE technique on uterine fibroid volume, symptom resolution, and quality of life.
Main Methods:
- Thirty patients with symptomatic uterine fibroids underwent UAE.
- Progressively larger calibrated gelatin sponge particles (355-500 μm, 500-710 μm, 710-1000 μm) were used.
- Pelvic MRI, clinical symptom assessment, and Uterine Fibroid Symptom and Quality of Life (UFS-QOL) scores were utilized for evaluation.
Main Results:
- Significant reduction in largest fibroid volume (56.23% at 3 months, 72.61% at 12 months).
- High infarction rates of dominant fibroids (91.27% at 3 months, 96% at 12 months).
- Marked improvement in menorrhagia and bulk-related symptoms, with a significant increase in UFS-QOL scores (43.13 to 11.88, p < 0.001). No major complications were reported.
Conclusions:
- UAE with progressively larger calibrated gelatin sponge particles is a safe and effective treatment for symptomatic uterine fibroids.
- This technique leads to substantial fibroid volume reduction and symptom relief.
- Improved quality of life and a favorable safety profile support its clinical utility.
