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A randomized controlled multimodal behavioral intervention trial for improving antiepileptic drug adherence
Amir H Pakpour1, Maryam Gholami2, Ravanbakhsh Esmaeili3
1Social Determinants of Health Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Epilepsy & Behavior : E&B
|September 29, 2015
Summary
Motivational interviewing (MI) significantly improved antiepileptic drug adherence in epilepsy patients. This multicomponent intervention, including planning and self-monitoring, enhances treatment effectiveness and patient outcomes.
Area of Science:
- Neurology
- Behavioral Science
- Clinical Pharmacy
Background:
- Medication nonadherence is a primary cause of treatment failure in epilepsy management.
- Improving adherence to antiepileptic drugs (AEDs) is crucial for effective epilepsy care.
Purpose of the Study:
- To evaluate the efficacy of a multicomponent intervention aimed at enhancing AED medication adherence in epilepsy patients.
- To compare a motivational interviewing (MI) based intervention with standard care for improving epilepsy treatment adherence.
Main Methods:
- A prospective, randomized multicenter trial involving 275 participants.
- Intervention group received three face-to-face motivational interviewing (MI) sessions with behavior change techniques.
- MI focused on change talk, self-motivation, barrier identification, and included action planning, self-monitoring, and family/healthcare team involvement.
Main Results:
- The intervention group demonstrated significantly higher medication adherence compared to the control group.
- Patients in the MI group reported stronger intention, greater perceived control over medication taking, and reduced medication concerns.
- Enhanced action planning, coping planning, and self-monitoring were observed in the intervention group.
Conclusions:
- Motivational interviewing (MI) is an effective clinical strategy for improving medication adherence in epilepsy patients.
- Combining MI with volitional interventions like action planning, coping planning, and self-monitoring boosts treatment effectiveness by enhancing adherence.
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