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Related Experiment Video

Updated: Apr 2, 2026

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
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Doege-Potter Syndrome.

N Ahluwalia1, R Attia1, A Green1

  • 1Guy's and St Thomas' NHS Foundation Trust , UK.

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|September 29, 2015
PubMed
Summary
This summary is machine-generated.

Doege-Potter syndrome, a rare condition causing low blood sugar, is linked to solitary fibrous tumors secreting insulin-like growth factor II. Surgical removal of the tumor effectively cures this paraneoplastic syndrome.

Keywords:
FibromaHypoglycaemiaInsulin-like growth factor IIThoracic surgery

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Area of Science:

  • Endocrinology
  • Oncology
  • Pathology

Background:

  • Doege-Potter syndrome is a rare paraneoplastic syndrome characterized by hypoinsulinaemic hypoglycemia.
  • It results from ectopic secretion of insulin-like growth factor II (IGF-II) prohormone, typically from a solitary fibrous tumor.

Observation:

  • A 76-year-old inpatient presented with severe hypoglycemia.
  • The patient was admitted for resection of a recurrent left-sided pleural tumor.

Findings:

  • Investigations confirmed true hypoglycemia and diagnosed Doege-Potter syndrome.
  • The underlying cause was identified as a solitary fibrous tumor secreting IGF-II prohormone.

Implications:

  • Complete surgical resection of the tumor led to a full recovery.
  • Early diagnosis and treatment are crucial to prevent hypoxic cerebral injury or death.