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The roles of CD147 in the progression of gliomas

Fei Fei1,2, Sanzhong Li3, Zhou Fei3

  • 1a 1 Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an 71032, P.R. China.

Expert Review of Anticancer Therapy
|September 29, 2015
PubMed

Insights

This review explores CD147

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Gliomas exhibit invasiveness, angiogenesis, and glycolysis, leading to poor prognosis.
  • Targeting these hallmarks is crucial for effective glioma therapy.
  • CD147 (basigin) is implicated in regulating tumor progression.

Purpose of the Study:

  • To review the multifaceted roles of CD147 in glioma development.
  • To evaluate CD147 as a potential prognostic biomarker.
  • To explore CD147 as a therapeutic target for gliomas.

Main Methods:

  • Literature review of studies on CD147 in gliomas.
  • Analysis of CD147's involvement in angiogenesis and glycolysis.
  • Examination of CD147's interaction with matrix metalloproteinases and monocarboxylate transporters.

Main Results:

  • CD147 significantly contributes to glioma invasiveness and angiogenesis.
  • CD147 promotes glycolysis in glioma cells.
  • CD147 influences the tumor microenvironment and progression.

Conclusions:

  • CD147 is a key regulator of critical glioma hallmarks.
  • CD147 shows promise as a prognostic biomarker for gliomas.
  • Targeting CD147 presents a potential therapeutic strategy for glioma treatment.
Keywords:
CD147angiogenesisgliomaglycolysisinvasiveness

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