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Values in Elderly People for Exhaled Nitric Oxide Study.

Mario Malerba1, Giovanni Damiani1, Giovanna E Carpagnano2

  • 11 Department of Internal Medicine, University of Brescia and ASST Spedali Civili , Brescia, Italy .

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Summary

Fractional exhaled nitric oxide (FeNO) reference values for adults over 65 were established. FeNO levels in healthy seniors are influenced by age but not sex, aiding clinical interpretation.

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Area of Science:

  • Respiratory Medicine
  • Geriatric Medicine
  • Pulmonology

Background:

  • The global population is aging, leading to an increased prevalence of elderly asthma patients.
  • Fractional exhaled nitric oxide (FeNO) is a key biomarker for diagnosing and monitoring asthma.
  • Current data lacks established FeNO reference values for healthy individuals over 65 with normal lung function.

Purpose of the Study:

  • To determine normal Fractional exhaled nitric oxide (FeNO) reference values for adults aged 65 and older.
  • To establish age- and sex-specific FeNO values in this demographic according to international guidelines.
  • To provide clinicians with reliable data for interpreting FeNO in elderly patients.

Main Methods:

  • FeNO was measured in 303 healthy, non-smoking adults over 65 years old.
  • Participants had normal spirometry values.
  • Measurements utilized the online single-breath technique with chemiluminescent detection.

Main Results:

  • FeNO levels ranged from 5.00 to 29.9 ppb, with a mean of 12.48 ± 2.80 ppb.
  • A significant association between FeNO levels and age was observed (p < 0.05).
  • Unlike younger populations, no significant difference in FeNO values was found between men and women in this age group.

Conclusions:

  • Age influences FeNO levels in healthy seniors, similar to younger adults.
  • FeNO values in healthy elderly men and women are comparable, differing from findings in younger populations.
  • These established reference values are crucial for accurate FeNO interpretation in clinical practice for the aging population.