Related Experiment Video
Updated: Apr 2, 2026

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction
Published on: December 20, 2014
Orthotopic urinary diversion
1USC/Norris Comprehensive Cancer Center, USC Institute of Urology, Los Angeles, California, USA.
Purpose Of Review:
Orthotopic urinary diversion has been performed for more than 30 years. Although it is considered to be the gold standard form of diversion in many centers of expertise, however it is uncommonly performed outside these institutions. The purpose of this article is to review the current indications and outcomes of orthotopic diversion with a focus on male patients and to explore potential barriers to wider dissemination of the technique.
Recent Findings:
Approximately 75% of patients undergoing radical cystectomy today are candidates for orthotopic diversion and in the absence of absolute contraindications, very few patients chose to undergo an ileal conduit for personal reasons. In a recent quality of life study, the orthotopic neobladder was better than ileal conduit in terms of global health status and physical functioning. In a prospective randomized trial comparing a refluxing versus nonrefluxing neobladder, there was no difference in renal function after 3 years. There is currently insufficient evidence to suggest improved perioperative outcomes with the use of minimally invasive techniques.
Summary:
There are very few absolute contraindications for an orthotopic neobladder, which remains the gold standard form of diversion at many centers of expertise. Surgeon experience and thorough preoperative counseling with realistic expectations can ensure optimal outcomes and patient satisfaction.
Related Concept Videos
Anatomy of the Genitourinary System II: Bladder and Urethra
Kidney Transplant II: Surgical Procedure
Imaging Studies VI: Voiding Cystourethrography and Cystography
Anatomy of the Genitourinary System I: Kidneys and Ureters
Urinary Tract Calculi VI: Surgical Management
Physiology of the Genitourinary System III: Urine Concentration and Dilution

