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Inflammation: a possible mechanism for a causative role of hyperuricemia/gout in cardiovascular disease

F Perez-Ruiz1, M A Becker2

  • 1a a Servicio de Reumatología, Hospital Universitario Cruces, Instituto de Investigación Biomédica BioCruces , Vizcaya , Spain.

Current Medical Research and Opinion
|September 29, 2015
PubMed

Insights

High uric acid levels and gout are linked to hypertension and kidney disease. Inflammation may explain how these conditions contribute to cardiovascular disease and metabolic syndrome.

Area of Science:

  • Nephrology
  • Cardiology
  • Rheumatology

Background:

  • Hyperuricemia and gout are recognized risk factors for hypertension, metabolic syndrome, vascular damage, and renal disease.
  • The causal relationship between hyperuricemia/gout and these comorbidities is not fully established.
  • Inflammation is hypothesized as a key mechanistic link.

Purpose of the Study:

  • To review the diverse factors contributing to hyperuricemia and gout.
  • To discuss the inflammatory mechanisms underlying hyperuricemia/gout.
  • To explore the impact of hyperuricemia and gout on cardiovascular and renal function.

Main Methods:

  • Literature review based on PubMed/Embase database searches.
  • Focus on articles examining hyperuricemia and its effects on cardiovascular and renal health.
  • Synthesis of current understanding regarding inflammation and endothelial dysfunction.

Main Results:

  • Hyperuricemia and gout negatively impact vascular function.
  • Pro-oxidant effects and reduced nitric oxide bioavailability contribute to endothelial dysfunction.
  • These mechanisms promote inflammation, hypertension, metabolic syndrome, and cardiovascular disease.

Conclusions:

  • Hyperuricemia and gout are associated with significant cardiovascular and renal risks.
  • Inflammation and endothelial dysfunction are central to the adverse effects of hyperuricemia and gout.
  • Understanding these pathways is crucial for managing associated chronic diseases.

Keywords:
Cardiovascular diseaseGoutHyperuricemiaInflammation

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