Engineering large animal models of human disease

Area of Science:

• Genomics
• Biotechnology
• Veterinary Medicine

Background:

• Gene editing tools offer unprecedented precision in modifying livestock genomes.
• The development of these tools facilitates the creation of novel animal models for disease research.

Purpose of the Study:

• To review current gene editing tools and their application in developing large animal models for diseases.
• To highlight the potential of genomic technology in advancing biomedical research and clinical translation.

Main Methods:

• Review of existing literature on gene editing technologies (e.g., CRISPR-Cas9).
• Analysis of applications in creating site-specific mutations in livestock genomes.
• Discussion of the utility of these models in comparative pathology.

Main Results:

• Gene editing enables the production of livestock carrying specific human disease mutations.
• A growing number of large animal models are becoming available through these genomic technologies.

Conclusions:

• Genomic technology is rapidly advancing the field of animal disease modeling.
• Enhanced animal model resources will accelerate human disease research and therapeutic development.
• Comparative pathology is crucial for the effective use of these models and clinical translation.