Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 2, 2026

A Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable Concentration Gradients
09:28

A Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable Concentration Gradients

Published on: April 19, 2010

12.7K

Towards an Endpoint Cell Motility Assay by a Microfluidic Platform.

Chuan-Feng Yeh, Wei Tai, Ching-Hui Lin

    IEEE Transactions on Nanobioscience
    |September 29, 2015
    PubMed
    Summary

    This study introduces a portable microfluidic device for endpoint analysis of cell motility, overcoming the limitations of time-lapse microscopy for high-throughput cancer drug screening. The device enables efficient assessment of cell migration inhibition by anti-cancer compounds.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Oncogenic <i>PIK3CA</i> mutation enhances tumor immunogenicity through the IRF1-NLRC5-MHC-I axis in urothelial carcinoma.

    Journal for immunotherapy of cancer·2026
    Same author

    A decoy virus strategy using plant-produced SARS-CoV-2 virus-like-particles to inhibit infection and lung injury.

    Journal of translational medicine·2026
    Same author

    A saliva-based surrogate associates with clinical outcome of oral potentially malignant disorders.

    British journal of cancer·2026
    Same author

    Mapping cellular and ECM heterogeneity in pulmonary fibrosis - insights from recent spatiomics studies.

    Cell biomaterials·2026
    Same author

    Low dose abemaciclib in heavily treated hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer.

    American journal of cancer research·2026
    Same author

    Two-Year Burden of Antibiotic Use for Prosthetic Joint Infection Following Total Knee Arthroplasty.

    Surgical infections·2026

    Area of Science:

    • Biomedical Engineering
    • Cell Biology
    • Cancer Research

    Background:

    • In vitro cell motility assays are crucial for studying cancer cell migration and anti-cancer drug efficacy.
    • Traditional microfluidic systems for cell motility analysis often require costly time-lapse microscopy, creating a bottleneck for high-throughput screening.
    • There is a need for more accessible and efficient methods to assess cell migration in response to drug treatments.

    Purpose of the Study:

    • To develop a portable microfluidic device for endpoint analysis of cell motility.
    • To overcome the limitations of time-lapse microscopy in microfluidic cell migration assays.
    • To demonstrate the device's utility in screening anti-cancer drug compounds.

    Main Methods:

    • Development of a portable microfluidic device with a cell alignment feature.

    More Related Videos

    Assessing Neural Stem Cell Motility Using an Agarose Gel-based Microfluidic Device
    12:55

    Assessing Neural Stem Cell Motility Using an Agarose Gel-based Microfluidic Device

    Published on: February 11, 2008

    12.3K
    Study of Cell Migration in Microfabricated Channels
    09:36

    Study of Cell Migration in Microfabricated Channels

    Published on: February 21, 2014

    12.5K

    Related Experiment Videos

    Last Updated: Apr 2, 2026

    A Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable Concentration Gradients
    09:28

    A Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable Concentration Gradients

    Published on: April 19, 2010

    12.7K
    Assessing Neural Stem Cell Motility Using an Agarose Gel-based Microfluidic Device
    12:55

    Assessing Neural Stem Cell Motility Using an Agarose Gel-based Microfluidic Device

    Published on: February 11, 2008

    12.3K
    Study of Cell Migration in Microfabricated Channels
    09:36

    Study of Cell Migration in Microfabricated Channels

    Published on: February 21, 2014

    12.5K
  • Utilizing endpoint analysis to assess cell migration after treatment.
  • Testing the device with MDA-MB-231 breast cancer cells treated with Indole-3-carbinol.

    • Main Results:

    • The developed microfluidic device enables endpoint analysis of cell motility.
    • The device successfully assessed the migration inhibitory effect of Indole-3-carbinol on breast cancer cells.
    • The cell alignment feature facilitates analysis of cell migration based on final positions.

    Conclusions:

    • The portable microfluidic device offers a cost-effective and high-throughput solution for cell motility analysis.
    • This technology has significant potential for screening anti-cancer drug compounds.
    • The endpoint analysis approach simplifies the experimental workflow for cell migration studies.