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Diphenylhydantoin and pulmonary function.

R J Smith, G C Man, S F Man

    The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
    |February 1, 1979
    PubMed
    Summary
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    Long-term use of diphenylhydantoin (DPH) in epileptic patients did not significantly impact pulmonary function compared to other anticonvulsants. Lung function tests showed no major differences between the DPH group and controls.

    Area of Science:

    • Pulmonary Medicine
    • Neurology
    • Pharmacology

    Background:

    • Epilepsy is a chronic neurological disorder affecting millions worldwide.
    • Anticonvulsant medications, such as diphenylhydantoin (DPH), are crucial for epilepsy management.
    • Potential pulmonary side effects of long-term anticonvulsant use require thorough investigation.

    Purpose of the Study:

    • To investigate the long-term effects of diphenylhydantoin (DPH) on pulmonary function in epileptic patients.
    • To compare pulmonary function in patients on DPH versus those on other anticonvulsants.
    • To identify any significant abnormalities in lung volume, airway function, or gas mixing.

    Main Methods:

    • Pulmonary function testing was conducted on 39 epileptic patients.
    • Twenty-one patients on long-term DPH (2-17 years) were compared to 18 patients on other anticonvulsants.

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  • Tests included lung volume, airway function, and alveolar gas mixing assessments.

    • Main Results:

    • Five patients in the DPH group exhibited lung volume abnormalities.
    • Four DPH patients had abnormal airway function, and five showed impaired gas mixing.
    • One control patient had lung volume abnormalities, two had airway issues, and five had gas mixing problems.
    • Statistical analysis revealed no significant differences between the DPH group, control group, or predicted values.

    Conclusions:

    • Long-term diphenylhydantoin (DPH) use in epileptic patients does not appear to cause significant pulmonary function abnormalities.
    • Pulmonary function in patients on DPH is comparable to those on alternative anticonvulsants.
    • Further research may explore specific mechanisms if subtle effects are suspected.