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Related Experiment Video

Updated: Apr 2, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Antibiotic dose optimization in critically ill patients.

M O Cotta¹, J A Roberts², J Lipman³

¹Burns Trauma and Critical Care Research Centre, University of Queensland, Brisbane, Queensland, Australia; Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia; School of Pharmacy, University of Queensland, Brisbane, Queensland, Australia.

Medicina Intensiva

|September 30, 2015

Summary

This summary is machine-generated.

Optimizing antibiotic dosing in critically ill patients is crucial for combating multi-drug resistance. Therapeutic drug monitoring and individualized dosing are key strategies for effective antibiotic use in intensive care units (ICUs).

Keywords:

Antibiotics Antibióticos Choque séptico Critically ill Críticamente enfermo Dose optimization Optimización de la dosis Sepsis grave Septic shock Severe sepsis

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Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

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Published on: April 18, 2019

Area of Science:

Pharmacology
Critical Care Medicine
Infectious Diseases

Background:

Judicious antibiotic use is vital for preserving efficacy against infections, especially with rising multi-drug resistance.
Intensive care units (ICUs) present unique challenges due to high antibiotic consumption and critically ill patients.
Altered patient physiology and organ dysfunction significantly impact antibiotic pharmacokinetics/pharmacodynamics.

Purpose of the Study:

To highlight the importance of antibiotic dose optimization in critically ill patients.
To discuss the influence of altered physiology and organ function on drug exposure.
To emphasize strategies for effective antibiotic therapy in intensive care settings.

Main Methods:

Review of pharmacokinetic/pharmacodynamic principles in critically ill patients.
Consideration of physiological changes in severe infections (sepsis, septic shock, VAP).
Analysis of the impact of extracorporeal support (CRRT, ECMO) on antibiotic exposure.

Main Results:

Critically ill patients exhibit altered physiology affecting drug exposure.
Conditions like severe sepsis, septic shock, and VAP require careful antibiotic dosing.
Continuous renal replacement therapy (CRRT) and extracorporeal membrane oxygenation (ECMO) significantly alter antibiotic levels.

Conclusions:

Antibiotic dose optimization in the ICU requires understanding altered physiology and pathogen-drug relationships.
Therapeutic drug monitoring (TDM) and individualized dosing are essential for effective antibiotic therapy.
Vigilance in adjusting antibiotic regimens is necessary, especially with extracorporeal support.