Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

756
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
756
Abnormal Proliferation02:23

Abnormal Proliferation

5.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
Skin Cancer01:30

Skin Cancer

6.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.6K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.2K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.2K
Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

4.8K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
4.8K
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

935
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
935

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-'n'-dry? A comparison of cannabis and alcohol use in drivers presenting to hospital after a vehicular collision.

Addiction (Abingdon, England)·2023
Same author

A rapid immunoblotting procedure for detecting serum antibodies to the lipopolysaccharide of Escherichia coli 0157.

Letters in applied microbiology·2021
Same author

Identification of a conjugative plasmid carrying antibiotic resistance and salmonella plasmid virulence (spv) genes in epidemic strains of Salmonella typhimurium phage type 193.

Letters in applied microbiology·2021
Same author

Default mode network connectivity as a predictor of post-traumatic stress disorder symptom severity in acutely traumatized subjects.

Acta psychiatrica Scandinavica·2009
Same author

Magnesium sulfate is effective for severe acute asthma treated in the emergency department.

The Western journal of medicine·2008
Same author

Systematic review of noninvasive positive pressure ventilation in severe stable COPD.

The European respiratory journal·2007
Same journal

Pain in People Living With Obesity: Baseline Multidimensional Profiles, Prevalence and Biopsychosocial Factors From a Cohort Study.

European journal of pain (London, England)·2026
Same journal

Utility of Vibration Perception Thresholds as a Biomarker of Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis.

European journal of pain (London, England)·2026
Same journal

Efficacy of Low-Dose Naltrexone in Women With Fibromyalgia Syndrome: A 12-Month Randomised, Double-Blind, Placebo-Controlled Single-Centre Clinical Trial (INNOVA Study).

European journal of pain (London, England)·2026
Same journal

Short-Term Nociceptive Memory: Reduced Discriminability and Multiple Encoding Biases.

European journal of pain (London, England)·2026
Same journal

Predicting Pain: Electroencephalography Signatures of Neural Integration During Experimental Tonic Thermal Pain.

European journal of pain (London, England)·2026
Same journal

Assessing Chronic Pain Processes Longitudinally: Psychometric Evaluation of the German 'Assessing Chronic Pain Processes' (ProCEss) Item Set.

European journal of pain (London, England)·2026
See all related articles

Related Experiment Video

Updated: Apr 2, 2026

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

13.3K

Malignancy-associated pruritus.

B Rowe1, G Yosipovitch1

  • 1Department of Dermatology and Temple Itch Center, Temple University School of Medicine, Philadelphia, Pennsylvania.

European Journal of Pain (London, England)
|September 30, 2015
PubMed
Summary
This summary is machine-generated.

Paraneoplastic itch, a systemic reaction to malignancy, often signals underlying cancers like lymphomas and skin cancers. Treatments targeting interleukin-31 show promise in alleviating this severe symptom.

More Related Videos

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.8K
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

15.7K

Related Experiment Videos

Last Updated: Apr 2, 2026

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

13.3K
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.8K
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

15.7K

Area of Science:

  • Oncology
  • Dermatology
  • Immunology

Background:

  • Malignancy-associated pruritus stems from local tumor effects or systemic reactions.
  • Paraneoplastic itch, a systemic reaction, can be an early indicator of underlying malignancy.
  • Commonly linked to lymphoproliferative disorders and non-melanoma skin cancers.

Purpose of the Study:

  • To explore the mechanisms and clinical significance of malignancy-associated pruritus.
  • To investigate the role of interleukin-31 in paraneoplastic itch, particularly in Cutaneous T-cell Lymphoma (CTCL).
  • To evaluate the efficacy of treatments targeting interleukin-31 in managing CTCL-associated pruritus.

Main Methods:

  • Review of existing literature on malignancy-associated pruritus.
  • Analysis of studies investigating the pathophysiology of CTCL-associated itch.
  • Correlation of treatment responses with serum interleukin-31 levels.

Main Results:

  • Paraneoplastic itch is frequently associated with lymphoproliferative malignancies and non-melanoma skin cancers.
  • Interleukin-31 is implicated as a key mediator in CTCL-associated pruritus.
  • Treatments like HDAC inhibitors and Mogamulizumab correlate with reduced itch and lower IL-31 levels.

Conclusions:

  • Paraneoplastic itch is a significant clinical sign of underlying malignancy.
  • Targeting interleukin-31 offers a potential therapeutic strategy for intractable pruritus in CTCL.
  • Further research into cytokine-mediated itch in cancer patients is warranted.