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Lymphocytic choriomeningitis virus infection induced by percutaneous exposure

O Aebischer1, P Meylan2, S Kunz3

  • 1Department of Internal Medicine, CHUV, 1011 Lausanne, Switzerland, oriane.aebischer@chuv.ch.

Occupational Medicine (Oxford, England)
|September 30, 2015
PubMed

Insights

An accidental workplace exposure led to lymphocytic choriomeningitis virus (LCMV) infection. The patient recovered fully after developing flu-like symptoms, pericarditis, and meningoencephalitis, highlighting the need for safety protocols.

Area of Science:

  • Virology
  • Infectious Diseases
  • Neuroscience

Background:

  • Lymphocytic choriomeningitis virus (LCMV) is a rodent-borne arenavirus.
  • Occupational exposure to LCMV can occur through percutaneous injury.
  • LCMV infection can lead to severe neurological complications.

Observation:

  • A healthcare worker sustained a percutaneous injury at work, leading to accidental LCMV inoculation.
  • The patient presented with a flu-like illness, progressing to pericarditis and meningoencephalitis.
  • Serological confirmation of LCMV infection was established via ELISA.

Findings:

  • Acquired LCMV infection following occupational percutaneous inoculation.
  • Clinical manifestations included systemic, cardiac, and neurological involvement.
  • Complete recovery was achieved with appropriate medical management.

Implications:

  • Highlights the risk of LCMV transmission in occupational settings.
  • Emphasizes the importance of implementing and adhering to safety protocols to prevent accidental inoculation.
  • Proposes a follow-up strategy for managing accidental LCMV exposures in the workplace.
Keywords:
Accidentslaboratory workersneedlestick injuries.

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