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Published on: September 20, 2011
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Particles from preformed polymers as carriers for drug delivery
K Miladi1, D Ibraheem2, M Iqbal2
1University of Lyon, France; Lyon 1 University, Villeurbanne, CNRS, UMR 5007, Laboratoire d'Automatique et de Génie des Procédés, LAGEP-CPE-308G, Villeurbanne, France ; University of Monastir, Laboratoire de pharmacie galénique, Rue Avicenne, 5000 Monastir, Tunisia.
EXCLI Journal
|September 30, 2015
Summary
This review covers preformed polymer techniques for creating micro/nano drug delivery carriers. It details polymer-solvent interactions, common polymers, and preparation methods for enhanced drug encapsulation.
Area of Science:
- Materials Science
- Polymer Chemistry
- Drug Delivery
Background:
- Biodegradable and biocompatible polymers are essential for drug encapsulation.
- Various particulate carriers (micro/nano) are prepared using diverse techniques.
- Effective drug delivery systems rely on well-characterized carriers.
Purpose of the Study:
- To review preformed polymer-based techniques for micro/nano carrier preparation.
- To describe polymer-solvent interactions relevant to encapsulation.
- To discuss polymer selection, preparation methods, and their applications in drug delivery.
Main Methods:
- Review of literature on preformed polymer-based techniques.
- Description of polymer-solvent interactions.
- Analysis of preparation principles and operating conditions.
- Discussion of polymer properties and characterization.
Main Results:
- Commonly used polymers and their properties are detailed.
- Principles and critical conditions for various preparation techniques are explained.
- Recent applications in drug delivery are highlighted.
- Insights into polymer-solvent interactions are provided.
Conclusions:
- Preformed polymer techniques offer versatile strategies for micro/nano carrier fabrication.
- Understanding polymer-solvent interactions is crucial for optimizing encapsulation.
- These techniques are vital for advancing controlled and targeted drug delivery systems.
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