Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

109
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
109
Drug Delivery: Overview01:16

Drug Delivery: Overview

1.1K
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
1.1K
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

308
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
308
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

309
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
309
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

2.0K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
2.0K
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

247
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
247

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated metabolomics, transcriptional, and physicochemical analysis reveals key metabolites and genes associated with somatic embryogenesis in Phyllostachys pubescens.

Scientific reports·2026
Same author

Oil-in-water nanoemulsification of peppermint oil enhances its antibacterial and antibiofilm activity.

Microbial pathogenesis·2026
Same author

Seed bio-priming with a cold-adapted rhizobacterium from the Himalayan phytobiome enhances cold resilience and biocontrol potential in fenugreek (Trigonella foenum-graceum): Genomic and physiological evidence.

Plant physiology and biochemistry : PPB·2026
Same author

Cobalt-based hybrid nanoflowers for the sustainable synthesis of a high-value health sugar D-sorbose.

International journal of biological macromolecules·2026
Same author

Development of multifunctional composite films based on κ-carrageenan/polyvinyl alcohol-polyethylene glycol copolymer blended with epigallocatechin gallate for strawberry preservation.

International journal of biological macromolecules·2026
Same author

Microplastic pollution in agricultural soils: Microbial interactions, food-chain risks, and management strategies with special reference to high-altitude agroecosystems.

Environmental research·2026
Same journal

Prevention of cognitive decline and dementia: Current evidence on lifestyle factors and dietary patterns.

EXCLI journal·2026
Same journal

Bidirectional relationship between metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus.

EXCLI journal·2026
Same journal

Triterpenoid saponins and ferroptosis: A membrane centered perspective.

EXCLI journal·2026
Same journal

Picroside III: novel multifunctional iridoid glycoside with promising antileukemic activity.

EXCLI journal·2026
Same journal

Nanotechnology-driven delivery of dexamethasone for arthritis: The role of liposomes.

EXCLI journal·2026
Same journal

Malnutrition-Sarcopenia Syndrome in older adults: Causes, consequences, and countermeasures.

EXCLI journal·2026
See all related articles

Related Experiment Video

Updated: Apr 1, 2026

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.6K

Nanoencapsulation for drug delivery.

Avnesh Kumari1, Rubbel Singla2, Anika Guliani1

  • 1Biotechnology Division, CSIR - Institute of Himalayan Bioresource Technology, Palampur-176061 (H.P.), India.

EXCLI Journal
|September 30, 2015
PubMed
Summary
This summary is machine-generated.

Nanoencapsulation in nanocarriers (NCs) improves drug delivery and reduces toxicity. This review covers synthesis, loading, release, and cellular response of various NCs for nanomedicine applications.

Keywords:
carbon nanotubedendrimersliposomesmagneticmicellesnanocarriers

More Related Videos

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

16.8K
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

8.1K

Related Experiment Videos

Last Updated: Apr 1, 2026

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.6K
Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

16.8K
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

8.1K

Area of Science:

  • Nanomedicine
  • Drug Delivery Systems
  • Materials Science

Background:

  • Nanoencapsulation of drugs in nanocarriers (NCs) is a key strategy in nanomedicine.
  • Efficient drug loading into NCs minimizes systemic toxicity and enhances therapeutic efficacy.
  • Targeting capabilities of NCs promote drug accumulation at disease sites.

Purpose of the Study:

  • To review synthesis methods for various nanocarriers.
  • To discuss drug loading efficiency and release mechanisms.
  • To highlight cellular responses and applications of nanoencapsulated drugs.

Main Methods:

  • Review of synthesis techniques for liposomes, micelles, carbon nanotubes, dendrimers, and magnetic NCs.
  • Analysis of drug loading capacities and release kinetics.
  • Evaluation of cellular interactions and in vivo/in vitro applications.

Main Results:

  • Various NCs demonstrate efficient drug loading and controlled release.
  • Targeted NCs show enhanced accumulation at diseased tissues.
  • Different NC platforms exhibit distinct cellular responses and therapeutic potentials.

Conclusions:

  • Nanoencapsulation offers a versatile platform for advanced drug delivery.
  • The choice of nanocarrier impacts drug efficacy, toxicity, and targeting.
  • Continued research in NCs promises significant advancements in nanomedicine.