Related Experiment Video
Updated: Apr 1, 2026
Preparation of Murine Submandibular Salivary Gland for Upright Intravital Microscopy
Published on: May 7, 2018
Photoacoustic imaging of salivary glands
Laurie J Rich1, Mukund Seshadri2
1Laboratory for Translational Imaging, Department of Molecular and Cellular Biophysics and Biochemistry, Roswell Park Cancer Institute, Buffalo, New York 14263, USA ; Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Abstract:
In this work, we utilized photoacoustic imaging (PAI) with co-registered ultrasound (US) to non-invasively assess salivary gland function in vivo. A significant increase in salivary gland oxygen saturation was observed on PAI within minutes after gustatory stimulation of healthy mice reflective of the hyperemic response associated with secretion of saliva. Good correlation was seen between PAI and Doppler sonography. Salivary adenoid cystic carcinomas showed higher oxygen saturation compared to surrounding salivary gland tissue. Our results demonstrate the potential clinical utility of PAI for visualization of salivary gland physiology and pathology.
More Related Videos
07:25Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
Published on: October 13, 2023
05:40Author Spotlight: Studying Macrophage-Epithelial Cell Interactions in Salivary Gland Regeneration After Injury
Published on: November 17, 2023
