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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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Iron Status of Cats with Chronic Kidney Disease

J Gest1, C Langston2, A Eatroff3

  • 1Animal Medical Center, New York, NY.

Journal of Veterinary Internal Medicine
|September 30, 2015
PubMed

Insights

Anemia in cats with chronic kidney disease (CKD) may stem from functional iron deficiency. Anemic CKD cats showed lower transferrin saturation (TSAT), suggesting iron is less available for red blood cell production.

Area of Science:

  • Veterinary Medicine
  • Hematology
  • Nephrology

Background:

  • Iron deficiency is a suspected cause of anemia in cats with chronic kidney disease (CKD).
  • Limited research exists on the iron status of cats suffering from CKD.

Purpose of the Study:

  • To compare iron status indicators in cats with CKD, healthy cats, and cats with nonrenal illness (NRI).
  • To compare iron status indicators in anemic versus nonanemic cats with CKD.

Main Methods:

  • Evaluated iron status in 39 healthy cats, 40 cats with CKD, and 34 cats with NRI.
  • Measured complete blood counts, serum chemistries, iron, total iron-binding capacity (TIBC), and ferritin; calculated transferrin saturation (TSAT).
  • Utilized nonparametric statistical testing for data analysis.

Main Results:

  • Total iron-binding capacity (TIBC) was significantly lower in cats with CKD compared to healthy cats.
  • Anemic cats with CKD exhibited significantly lower transferrin saturation (TSAT) compared to nonanemic cats with CKD.
  • No significant differences were found in iron or ferritin concentrations among the groups.

Conclusions:

  • Anemia in cats with CKD is associated with a functional iron deficiency, where iron is less available for erythropoiesis.
  • This suggests a need for further investigation into iron metabolism and management strategies in feline CKD.
Abstract

Keywords:
AnemiaFelineFerritinRenal

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