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Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
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Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) levels in patients with overt and subclinical

Cihangir Erem1, Nadim Civan1, Hulya Coskun1

  • 1Department of Internal Medicine, Division of Endocrinology and Metabolism, Trabzon, Turkey.

Clinical Endocrinology
|September 30, 2015
PubMed

Insights

Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) is elevated in hyperthyroidism, indicating platelet activation and endothelial dysfunction. Treatment with antithyroid drugs (ATD) significantly reduced SCUBE1 levels.

Area of Science:

  • Endocrinology
  • Cardiovascular Research
  • Biomarker Discovery

Background:

  • Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) is linked to platelet activation in thrombotic diseases.
  • Hyperthyroidism, including overt (OHyper) and subclinical (SHyper) forms, is associated with endothelial and platelet dysfunction.
  • No prior studies have investigated SCUBE1 levels in hyperthyroid patients.

Purpose of the Study:

  • To evaluate SCUBE1 concentrations in patients with SHyper and OHyper.
  • To assess the impact of antithyroid drug (ATD) therapy on circulating SCUBE1 levels.

Main Methods:

  • Prospective study including 45 untreated OHyper patients, 20 untreated SHyper patients, and 30 healthy controls.
  • Evaluation of biochemical and hormonal parameters before and after ATD treatment.
  • Measurement of SCUBE1 levels in all participants.

Main Results:

  • SCUBE1 levels were significantly higher in both SHyper and OHyper patients compared to controls (P < 0.0001 and P = 0.002, respectively).
  • No significant difference in SCUBE1 levels was observed between OHyper and SHyper patients.
  • Plasma SCUBE1 levels significantly decreased after ATD treatment in both patient groups (P < 0.05).

Conclusions:

  • Elevated SCUBE1 in hyperthyroidism suggests increased platelet activation and potential endothelial dysfunction.
  • SCUBE1 may serve as a reliable biomarker for endothelial damage in hyperthyroidism, particularly in the subclinical stage.
  • These findings highlight SCUBE1's potential role in assessing cardiovascular risk in hyperthyroid patients.
Abstract

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