Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Bone marrow immunosuppressive states associate with survival after guadecitabine and atezolizumab therapy in HMA-R/R MDS.

Blood neoplasia·2026

Same author

Structure-guided design of 7-azaindole DNMT1 inhibitors active against hypomethylating agent-resistant acute myeloid leukemia.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases.

Science translational medicine·2026

Same author

Pembrolizumab and epigenetic modification with azacitidine reshapes the tumor microenvironment of platinum-resistant epithelial ovarian cancer: a phase 2 non-randomized clinical trial.

Communications medicine·2026

Same author

Importance of De Novo Gene Evolution to Emerging Viral Threats: The ORF10 Strain-Restricted Orphan Gene of SARS-CoV-2 Promotes Pathogenesis.

Molecular biology and evolution·2025

Same journal

HOTAIR at the metabolic crossroads: lncRNA control of carbohydrate and lipid metabolism.

Epigenomics·2026

Same journal

Long-term molecular embedding of early life adversity: leukocyte DNA methylation and gene expression associations from childhood to young adulthood.

Epigenomics·2026

Same journal

Overview of transcriptomics and epigenomics approaches in the diagnosis, prognosis, and therapeutics of primary brain cancers.

Epigenomics·2026

Same journal

Ultra-sensitive urine DNA methylation test enables early and accurate detection of bladder cancer.

Epigenomics·2026

Same journal

Promoter methylation-associated brain-enriched long noncoding RNAs in glioblastoma: a multi-cohort public epigenomic re-analysis.

Epigenomics·2026

Same journal

Clinical diagnostic utility of <i>MGMT</i> promoter methylation.

Epigenomics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 1, 2026

Imaging Glioma Initiation In Vivo Through a Polished and Reinforced Thin-skull Cranial Window

Imaging Glioma Initiation In Vivo Through a Polished and Reinforced Thin-skull Cranial Window

Published on: November 20, 2012

Interview with Stephen B Baylin.

Stephen B Baylin¹

¹The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.

|September 30, 2015

Summary

This summary is machine-generated.

Dr. Stephen B. Baylin researches cancer epigenetics, focusing on how genetic modifications influence tumor suppressor gene silencing and cancer progression. His work investigates variations in tumor cells and differentiation in cancers like lung and thyroid carcinoma.

More Related Videos

Experimental Human Pneumococcal Carriage

Experimental Human Pneumococcal Carriage

Published on: February 15, 2013

Imaging pHluorin-tagged Receptor Insertion to the Plasma Membrane in Primary Cultured Mouse Neurons

Imaging pHluorin-tagged Receptor Insertion to the Plasma Membrane in Primary Cultured Mouse Neurons

Published on: November 20, 2012

Related Experiment Videos

Last Updated: Apr 1, 2026

Imaging Glioma Initiation In Vivo Through a Polished and Reinforced Thin-skull Cranial Window

Imaging Glioma Initiation In Vivo Through a Polished and Reinforced Thin-skull Cranial Window

Published on: November 20, 2012

Experimental Human Pneumococcal Carriage

Experimental Human Pneumococcal Carriage

Published on: February 15, 2013

Imaging pHluorin-tagged Receptor Insertion to the Plasma Membrane in Primary Cultured Mouse Neurons

Imaging pHluorin-tagged Receptor Insertion to the Plasma Membrane in Primary Cultured Mouse Neurons

Published on: November 20, 2012

Area of Science:

Oncology
Cancer Biology
Genetics

Background:

Dr. Stephen B. Baylin, a leading figure at Johns Hopkins, specializes in cancer biology and epigenetics.
His academic journey includes Duke University School of Medicine and the National Heart and Lung Institute.
He has dedicated his career to understanding the genetic underpinnings of cancer.

Discussion:

Focuses on epigenetics: modifications to DNA that alter cell behavior without changing the DNA sequence.
Investigates the silencing of tumor suppressor genes as a key mechanism in cancer development.
Examines the origins of tumor cell variations and their role in disease progression.

Key Insights:

Elucidates mechanisms of tumor cell heterogeneity and differentiation in cancers.
Specific research includes medullary thyroid carcinoma and small-cell lung carcinoma.
His work contributes to understanding the fundamental biology of cancer.

Outlook:

Continued exploration of epigenetic modifications in cancer.
Potential for novel therapeutic targets based on epigenetic regulation.
Advancing the field of cancer genetics and personalized medicine.