Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Hemostasis01:05

Introduction to Hemostasis

17.1K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
17.1K
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

15.4K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
15.4K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

2.4K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.4K
Disorders of Hemostasis01:24

Disorders of Hemostasis

2.8K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.8K
Coagulation01:09

Coagulation

12.0K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
12.0K
Coagulation01:06

Coagulation

1.7K
Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mohs surgery for melanoma: Assessing medicolegal risk.

Journal of the American Academy of Dermatology·2025
Same author

Pilar Cyst of the Dorsal Hand: A Rare Presentation of a Common Cyst.

Cureus·2024
Same author

Promoter of lncRNA <i>MORT</i> is aberrantly methylated in colorectal cancer.

Nucleosides, nucleotides & nucleic acids·2024
Same author

Characterization of Blood-borne Pathogen Exposures During Dermatologic Procedures: The Mayo Clinic Experience.

Cutis·2023
Same author

Adipose trimming and reducing risk of graft falling on the floor.

Journal of the American Academy of Dermatology·2022
Same author

Damage to the Temporal Branch of the Facial Nerve From Mohs Micrographic Surgery.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2022
Same journal

A Comprehensive Review of Dermal Fillers and Biostimulators for Neck Rejuvenation.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same journal

Reconstruction of a Defect Involving the Upper Lip, Alar Base, and Medial Cheek.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same journal

Extramammary Paget Disease: A Single-Center, Clinical Analysis.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same journal

Frozen Section Biopsy as a Real-Time Decision-Support Tool in Dermatologic Surgery: A Retrospective Review.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same journal

MSH6-Associated Muir-Torre Syndrome Diagnosed in the Setting of Cutaneous Squamous Cell Carcinoma.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same journal

How We Do It: Selection of Hidradenitis Suppurativa Lesions for Deroofing Based on Surface Contour.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
See all related articles

Related Experiment Video

Updated: Apr 1, 2026

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

9.9K

Undermining and Hemostasis.

David L Chen1, Ekama O Carlson, Ramin Fathi

  • 1Department of Dermatology, University of Colorado School of Medicine, Aurora, Colorado.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|September 30, 2015
PubMed
Summary
This summary is machine-generated.

Proper surgical undermining and hemostasis are crucial for successful wound closure. Optimizing these techniques minimizes complications and improves surgical outcomes in dermatologic procedures.

More Related Videos

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.5K
The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
06:59

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

97

Related Experiment Videos

Last Updated: Apr 1, 2026

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

9.9K
A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.5K
The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
06:59

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

97

Area of Science:

  • Surgical Techniques
  • Dermatologic Surgery

Background:

  • Undermining and hemostasis are fundamental surgical techniques.
  • These methods significantly influence surgical results.

Purpose of the Study:

  • Review mechanisms and techniques of undermining and hemostasis.
  • Emphasize advantages and limitations of each modality.

Main Methods:

  • Literature search of the PubMed database.
  • Keywords: undermining, hemostasis, electrosurgery.

Main Results:

  • Appropriate undermining (depth, width) is essential for tissue mobility in closures.
  • Both excessive and inadequate undermining can impair healing.
  • Hemostasis techniques include pressure, ligation, topical agents, and electrosurgery.
  • Dermatologic surgeons must select appropriate hemostasis methods.
  • Electrosurgery requires careful application to prevent complications.

Conclusions:

  • Optimizing hemostasis and undermining enhances dermatologic surgical closures.
  • Improved understanding leads to fewer complications.