Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

446
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
446
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

321
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
321
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

1.0K
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
1.0K
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

591
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
591
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

562
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
562
Myocarditis IV: Nursing Management01:22

Myocarditis IV: Nursing Management

359
Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
359

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Haplotype-resolved long-read sequencing reveals parent-of-origin effects of tandem-repeat variation in autism spectrum disorder.

Science bulletin·2026
Same author

The genetic spectrum of LRRK2 variants in Parkinson's disease: findings from a large Chinese cohort.

NPJ Parkinson's disease·2026
Same author

Large-scale profiling of blood microbial signatures in patients with Parkinson's disease and its association with disease progression: a cross-sectional study.

EBioMedicine·2026
Same author

Shared genetic architecture between sleep traits and cardiometabolic diseases.

EBioMedicine·2026
Same author

Gut microbiota modulation via repeated donor fecal transplantation improves motor and gastrointestinal symptoms in drug-naïve Parkinson's disease: a randomized phase 2 trial.

Signal transduction and targeted therapy·2026
Same author

Short tandem repeat expansions in patients with neurodegenerative dementia.

EBioMedicine·2026
Same journal

Increased awareness around an ultra-rare disease can improve diagnosis delays: the French example in primary hyperoxalurias.

Orphanet journal of rare diseases·2026
Same journal

Patient-driven surveys of mucopolysaccharidoses revealed patient-reported outcomes in the Japan MPS patient and family group.

Orphanet journal of rare diseases·2026
Same journal

Mapping the landscape of treatable inborn errors of metabolism: a systematic gene-level evaluation based on the ICIMD classification.

Orphanet journal of rare diseases·2026
Same journal

Cognitive function in adult NF1 patients without other cognitive disorders: a cross-sectional study.

Orphanet journal of rare diseases·2026
Same journal

Real-world insights into neurodevelopmental outcomes amongst people with congenital hyperinsulinism.

Orphanet journal of rare diseases·2026
Same journal

Care of patients with Phenylketonuria (PKU) in Germany - a claims data analysis from 2013 to 2023.

Orphanet journal of rare diseases·2026
See all related articles

Related Experiment Video

Updated: Apr 1, 2026

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
06:31

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

9.3K

Primary erythromelalgia: a review.

Zhaoli Tang1, Zhao Chen2, Beisha Tang3,4,5

  • 1Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya road, Changsha, 410008, Hunan, China. zhaoli.tang@outlook.com.

Orphanet Journal of Rare Diseases
|October 1, 2015
PubMed
Summary
This summary is machine-generated.

Primary erythromelalgia (PE) is a rare genetic disorder causing severe extremity pain. Mutations in the SCN9A gene affecting Nav1.7 channels are the primary cause, leading to a need for targeted therapies.

More Related Videos

Minimal Erythema Dose MED Testing
06:24

Minimal Erythema Dose MED Testing

Published on: May 28, 2013

43.2K
Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.9K

Related Experiment Videos

Last Updated: Apr 1, 2026

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
06:31

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

9.3K
Minimal Erythema Dose MED Testing
06:24

Minimal Erythema Dose MED Testing

Published on: May 28, 2013

43.2K
Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.9K

Area of Science:

  • Genetics
  • Neurology
  • Rare Diseases

Background:

  • Primary erythromelalgia (PE) is a rare autosomal dominant neuropathy.
  • Characterized by recurrent burning pain, warmth, and redness in extremities.
  • Onset typically occurs in the first decade of life, with symptoms often worsening over time.

Purpose of the Study:

  • To review the genetic etiology of PE, focusing on SCN9A gene mutations.
  • To explore the effects of these mutations on Nav1.7 channel electrophysiological properties.
  • To propose a genotype-channelopathy-phenotype correlation network for PE.

Main Methods:

  • Review of existing literature on PE and SCN9A gene.
  • Analysis of mutation effects on Nav1.7 channel function.
  • Correlation of genetic findings with clinical phenotypes.

Main Results:

  • PE is primarily caused by mutations in the SCN9A gene, encoding the Nav1.7 sodium channel.
  • These mutations lead to channel dysfunction, resulting in the characteristic symptoms of PE.
  • A genotype-channelopathy-phenotype network is proposed to explain disease mechanisms.

Conclusions:

  • Understanding the SCN9A genotype-channelopathy-phenotype correlation is crucial for PE.
  • This network can guide the development of novel, targeted therapeutics for PE.
  • Current treatments are unsatisfactory, highlighting the need for improved therapeutic strategies.