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Translating the effects of mTOR on secretory senescence

Kosuke Tomimatsu1, Masashi Narita1

  • 1University of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, UK.

Nature Cell Biology
|October 1, 2015
PubMed

Insights

Cellular senescence triggers a secretory phenotype impacting tissues. The mammalian target of rapamycin (mTOR) pathway controls this by regulating gene expression and mRNA stability.

Area of Science:

  • Cellular and Molecular Biology
  • Aging Research
  • Biochemistry

Background:

  • Cellular senescence is a state of irreversible growth arrest.
  • Senescence-associated secretory phenotype (SASP) involves secreted factors influencing the microenvironment.
  • The role of mTOR in regulating senescence was previously unclear.

Discussion:

  • The mammalian target of rapamycin (mTOR) pathway is a key regulator of protein synthesis.
  • mTOR influences cellular senescence by controlling gene transcription.
  • mTOR also modulates mRNA translation and stabilization, impacting SASP.

Key Insights:

  • mTOR is a central regulator of the senescence-associated secretory phenotype (SASP).
  • The pathway affects SASP through transcriptional, translational, and post-transcriptional mechanisms.
  • This finding links a major metabolic regulator to a fundamental aging process.

Outlook:

  • Further investigation into mTOR's role in aging and age-related diseases.
  • Therapeutic targeting of mTOR to modulate SASP and its consequences.
  • Exploring downstream targets of mTOR in senescence for novel interventions.

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