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Efficient singlet oxygen generation from sugar pendant C60 derivatives for photodynamic therapy
Shigenobu Yano1, Masami Naemura, Akio Toshimitsu
1Graduate School of Material Science, Nara Institute of Science and Technology, 8916-5, Takayama-cho, Ikoma, Nara 630-0192, Japan. yano-shigenobu@ms.naist.jp.
Abstract:
The amidation reaction between C60 with an activated ester group (1) and acetylated Glc (AcGlc) with an amino group (2) was performed to yield the target AcGlc-pendant C60 compound (3). The water soluble deacetylated compound, Glc-pendant C60 compound (4), exhibited high photocytotoxicity against HeLa cells due to the more efficient singlet oxygen generation as compared with that of Glc-pendant azafulleroids.
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