Jove
Visualize
Contact Us

Related Experiment Videos

A general criterion for molecular recognition: implications for chiral interactions.

S Topiol1

  • 1Department of Medicinal Chemistry, Berlex Laboratories, Inc., Cedar Knolls, New Jersey 07927.

Chirality
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Determining the roles of different chain fragments in recognition of immunoglobulin fold.

Protein engineering·2002
Same author

Recognition of protein structure: determining the relative energetic contributions of beta-strands, alpha-helices and loops.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing·2000
Same author

Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1).

Journal of medicinal chemistry·1999
Same author

Heterologously expressed inner lipoyl domain of dihydrolipoyl acetyltransferase inhibits ATP-dependent inactivation of pyruvate dehydrogenase complex. Identification of important amino acid residues.

The Biochemical journal·1998
Same author

A computational study of a host-guest complex.

Journal of molecular recognition : JMR·1997
Same author

The computational design of test compounds with potentially specific biological activity: histamine-H2 agonists derived from 5-HT/H2 antagonists.

Journal of computer-aided molecular design·1991
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

A new criterion based on distance matrices explains molecular recognition, particularly for chiral compounds. This method offers a clear understanding of chiral recognition mechanisms and resolving agent properties.

Area of Science:

  • Molecular Chemistry
  • Analytical Chemistry
  • Physical Chemistry

Background:

  • Molecular recognition is crucial in chemistry and biology.
  • Understanding chiral recognition is essential for pharmaceuticals and materials science.
  • Existing models for chiral recognition can be complex and lack a unified explanation.

Purpose of the Study:

  • To formulate a general criterion for molecular recognition.
  • To provide an objective and simple explanation for chiral compound recognition.
  • To unify and explain various chiral recognition models and mechanisms.

Main Methods:

  • Formulation of a general recognition criterion based on distance matrices.
  • Analysis of complexes between compounds and a resolving agent.

Related Experiment Videos

  • Application of the criterion to explain chiral recognition phenomena.

    • Main Results:

    • A general criterion for molecular recognition is established using distance matrix inequalities.
    • The criterion objectively explains chiral recognition, unifying one-, two-, and three-point attachment models.
    • Symmetry requirements and reciprocal relationships of chiral resolving agents are derived.

    Conclusions:

    • Distance matrix comparison provides a fundamental basis for molecular recognition.
    • This approach offers a simplified and unified framework for understanding chiral recognition.
    • The method is applicable to diverse experimental findings and resolving agent properties.