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Updated: Apr 1, 2026

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
Published on: March 26, 2018
Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication
Tünde Szatmári1, Rita Ötvös1, Anders Hjerpe1
1Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, F-46, 141 86 Stockholm, Sweden.
Abstract:
Syndecan-1, a cell surface heparan sulfate proteoglycan, is critically involved in the differentiation and prognosis of various tumors. In this review, we highlight the synthesis, cellular interactions, and the signalling pathways regulated by syndecan-1. The basal syndecan-1 level is also crucial for understanding the sequential changes involving malignant transformation, tumor progression, and advanced or disseminated cancer stages. Moreover, we focus on the cellular localization of this proteoglycan as cell membrane anchored and/or shed, soluble syndecan-1 with stromal or nuclear accumulation and how this may carry different, highly tissue specific prognostic information for individual tumor types.
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