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Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Related Experiment Video

Updated: Apr 1, 2026

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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Overcome Cancer Cell Drug Resistance Using Natural Products.

Pu Wang1, Hua Li Yang1, Ying Juan Yang1

  • 1School of Life Sciences, Shanxi University, Taiyuan, Shanxi 030006, China.

Evidence-Based Complementary and Alternative Medicine : Ecam
|October 1, 2015
PubMed
Summary

Natural products show promise in overcoming chemotherapy drug resistance in cancer. This review summarizes Chinese research on natural compounds, including preclinical and clinical studies, highlighting their potential for improving cancer treatment outcomes.

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Area of Science:

  • Pharmacology
  • Oncology
  • Natural Products Chemistry

Background:

  • Chemotherapy is a primary cancer treatment, but drug resistance and toxicity limit its efficacy.
  • Managing chemotherapy drug resistance is crucial for successful cancer treatment.
  • Numerous reports in Chinese literature suggest natural products can overcome cancer cell drug resistance.

Purpose of the Study:

  • To review and summarize Chinese research on natural products for overcoming cancer cell drug resistance.
  • To categorize existing research into in vitro, serum pharmacology, in vivo, and clinical studies.
  • To identify novel natural compounds with anti-drug resistance activity.

Main Methods:

  • Systematic review of Chinese literature on natural products and cancer drug resistance.
  • Categorization of studies based on experimental models (cell lines, animals, clinical).
  • Identification and analysis of compounds reported to possess anti-drug resistance properties.

Main Results:

  • Fourteen single compounds were identified with novel anti-drug resistance activity.
  • In vitro studies demonstrated compounds overcoming resistance at non-toxic concentrations by affecting drug transporters, detoxification, or apoptosis.
  • In vivo studies and clinical data showed efficacy of single compounds, extracts, and formulas against drug resistance.

Conclusions:

  • Natural products, including single compounds and herbal formulations, exhibit significant potential in overcoming cancer drug resistance.
  • Evidence from preclinical and clinical studies supports the use of natural compounds for managing chemotherapy resistance.
  • This review provides a comprehensive dataset to facilitate the therapeutic development of natural products for clinical application in cancer treatment.