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Characteristics and Antibiotic Resistance of Urinary Tract Pathogens Isolated From Punjab, Pakistan

Muhammad Sohail1, Mohsin Khurshid2, Hafiz Ghulam Murtaza Saleem1

  • 1Department of Microbiology and Molecular Genetics, Quaid-e-Azam Campus, University of the Punjab, Lahore-54590, Pakistan.

Jundishapur Journal of Microbiology
|October 1, 2015
PubMed

Insights

Urinary tract infections (UTIs) are common, especially in females. Escherichia coli is the most frequent cause, showing high resistance to many antibiotics but susceptibility to imipenem, meropenem, and cefoperazone.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Urinary tract infections (UTIs) represent a significant global health burden, with a high incidence in the general population.
  • UTIs are the most common type of infectious disease worldwide.

Purpose of the Study:

  • To characterize uropathogenic isolates from patients in Punjab, Pakistan.
  • To assess the antimicrobial susceptibility patterns of these isolates.

Main Methods:

  • Analysis of 1429 urine samples over 14 months.
  • Isolation and identification of uropathogens from positive cultures.
  • Antimicrobial susceptibility testing using the disc diffusion method.

Main Results:

  • Females constituted the majority (67%) of UTI cases.
  • Escherichia coli was the predominant pathogen (62%), followed by E. faecalis and Candida.
  • E. coli exhibited high resistance to common antibiotics like cephalexin (95%) and ampicillin (84%), but showed high susceptibility to imipenem (97%), meropenem (97%), and piperacillin (96%).

Conclusions:

  • Broad-spectrum antibiotics including imipenem, meropenem, and fosfomycin are recommended for empirical UTI treatment.
  • High resistance rates to older antibiotics necessitate updated treatment guidelines.
Abstract

Keywords:
Antimicrobial DrugsEscherichia coliUrinary Tract Infections

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