A Case of Recurrent Kikuchi-Fujimoto Disease

Kikuchi-Fujimoto Disease (KFD) is a benign, self-limited, inflammatory disorder, first reported in Japan. This condition is more prevalent among women and typically occurs in the third decade of life. It normally manifests as persistent, isolated cervical adenopathy with a recurrence rate of 3%. The identification of this condition is of high significance, given the risk of misdiagnosis with other disorders such as malignant lymphoma and extensive necrosis.

The patient was a 32-year-old female diagnosed with Kikuchi-Fujimoto disease via neck lymph node biopsy in August 2006 in the city of Mashhad, Iran. The disease regressed with proper follow-up, although after eight years the patient was readmitted to the hospital with severe weight loss, high fever, and uncommon symptoms of generalized adenopathy in cervical, axillary and inguinal regions.

Although KFD is an uncommon condition, it should be featured in the list of differential diagnoses of tender lymphadenopathy, especially lymphadenopathy localized to the cervical region. We reported a case of KFD with a prolonged relapse of eight years. Full recovery with a good response to corticosteroid regimen was achieved after the recurrence.