Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

767
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
767
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

1.3K
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
1.3K
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

591
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
591
Blood Pressure Imbalances and Circulatory Shock01:24

Blood Pressure Imbalances and Circulatory Shock

1.9K
Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
1.9K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

1.2K
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
1.2K
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

3.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Valvular Shock in the Cardiac Intensive Care Unit: Perioperative Care for Transcatheter Valve Interventions.

Cardiology clinics·2026
Same author

THE SOCIETY OF CRITICAL CARE CARDIOLOGY - RATIONALE, BLUEPRINT, AND LESSONS LEARNED IN THE CREATION OF A NEW MULTIDISCIPLINARY PROFESSIONAL ORGANIZATION.

American heart journal·2026
Same author

Evaluating possible treatment effect heterogeneity in a randomized trial of milrinone versus dobutamine in cardiogenic shock.

Critical care (London, England)·2026
Same author

Reply: CICU Workforce Survey: Interpret With Caution.

JACC. Advances·2026
Same author

Pressure-Adjusted Heart Rate by Echocardiography and Mortality in the Cardiac Intensive Care Unit.

JACC. Advances·2026
Same author

Echocardiographic correlates of acute kidney injury in cardiac intensive care unit patients.

International journal of cardiology·2026

Related Experiment Video

Updated: Apr 1, 2026

Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest
08:30

Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest

Published on: August 6, 2015

12.2K

Myocardial Dysfunction and Shock after Cardiac Arrest.

Jacob C Jentzer1, Meshe D Chonde2, Cameron Dezfulian3

  • 1Division of Cardiology, UPMC Heart and Vascular Institute, University of Pittsburgh Presbyterian Hospital, 200 Lothrop Street, Pittsburgh, PA 15213, USA ; Department of Critical Care Medicine, University of Pittsburgh Presbyterian Hospital, 200 Lothrop Street, Pittsburgh, PA 15213, USA.

Biomed Research International
|October 1, 2015
PubMed
Summary

Post-cardiac arrest myocardial dysfunction, affecting heart function after resuscitation, is common. Its exact impact on patient outcomes requires further investigation to guide therapeutic strategies.

More Related Videos

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs
08:19

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs

Published on: July 12, 2022

3.7K
Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

3.8K

Related Experiment Videos

Last Updated: Apr 1, 2026

Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest
08:30

Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest

Published on: August 6, 2015

12.2K
Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs
08:19

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs

Published on: July 12, 2022

3.7K
Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

3.8K

Area of Science:

  • Cardiology
  • Critical Care Medicine
  • Physiology

Background:

  • Postarrest myocardial dysfunction, characterized by low cardiac output and impaired ventricular function, affects many patients after cardiac arrest.
  • Hypotension and shock are common post-resuscitation, with shock consistently linked to adverse outcomes, unlike myocardial dysfunction whose outcome association is less clear.
  • Myocardial dysfunction post-cardiac arrest stems from pre-existing cardiac issues compounded by resuscitation insults, including ischemia/reperfusion injury and inflammatory responses.

Purpose of the Study:

  • To review the mechanisms and clinical implications of myocardial dysfunction following cardiac arrest.
  • To discuss current hemodynamic stabilization strategies and identify knowledge gaps.
  • To highlight the need for further research into the role of postarrest myocardial dysfunction and its therapeutic targets.

Main Methods:

  • Literature review of postarrest myocardial dysfunction.
  • Analysis of pathophysiological mechanisms including ischemia/reperfusion and inflammatory pathways.
  • Synthesis of current hemodynamic management principles and research needs.

Main Results:

  • Impaired left ventricular systolic function is observed in approximately two-thirds of resuscitated patients.
  • The precise association between myocardial dysfunction and patient outcomes remains less defined compared to shock.
  • Pathophysiological mechanisms involve ischemia/reperfusion, inflammatory cytokines, and catecholamine toxicity.

Conclusions:

  • Postarrest myocardial dysfunction shares pathophysiological similarities with conditions like sepsis and stress-induced cardiomyopathy.
  • Hemodynamic support involves optimizing preload, vasopressors, and inotropes.
  • Further research is crucial to elucidate the impact of myocardial dysfunction on cardiac arrest outcomes and develop targeted therapies.