Computerised working-memory focused cognitive remediation therapy for psychosis--A preliminary study

Area of Science:

• Neuroscience
• Psychiatry
• Cognitive Psychology

Background:

• Cognitive deficits are a primary feature of schizophrenia and related psychotic disorders, significantly impacting daily functioning.
• Behavioral interventions show promise for cognitive remediation, but optimizing delivery for cost-effectiveness is crucial.

Purpose of the Study:

• To evaluate a novel, internet-delivered cognitive remediation (CR) program focused on working memory.
• To assess the impact of this CR training, supplemented by weekly telephone support, on cognitive difficulties.

Main Methods:

• A non-randomized study involving 56 participants diagnosed with psychosis.
• Participants received either 8 weeks of CR training (approx. 20 hours) or treatment as usual (TAU).
• Cognitive functions, including general cognitive ability, working memory, and episodic memory, were assessed pre- and post-intervention.

Main Results:

• CR training led to significant improvements in trained working memory tasks.
• Participants in the CR group also showed significant gains in verbal episodic memory.
• No significant changes in general cognitive ability were observed; effect sizes for memory improvements were comparable to in-person training.

Conclusions:

• Internet-based working memory training demonstrates efficacy as a cognitive remediation therapy for individuals with psychosis.
• The study highlights the potential of accessible, internet-delivered interventions while acknowledging implementation challenges.