Related Experiment Video
Updated: Apr 1, 2026
07:50
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
16.6K
CHIKUNGUNYA-ASSOCIATED UVEITIS AND EXUDATIVE RETINAL DETACHMENT: A CASE REPORT
Nicole K Scripsema1, Emile Sharifi, C Michael Samson
1*Department of Ophthalmology, The New York Eye and Ear Infirmary of Mount Sinai, New York, New York; and †Icahn School of Medicine at Mount Sinai, New York, New York.
Retinal Cases & Brief Reports
|October 1, 2015
Summary
This case report details the first U.S. instance of bilateral granulomatous panuveitis caused by chikungunya fever. The patient
Area of Science:
- Ophthalmology
- Infectious Diseases
- Virology
Background:
- Chikungunya fever is an emerging mosquito-borne viral illness.
- Ocular manifestations of chikungunya virus infection are increasingly reported.
- Uveitis is a significant potential complication of chikungunya fever.
Observation:
- A U.S. citizen returning from the Dominican Republic developed bilateral granulomatous panuveitis with exudative retinal detachments.
- Diagnosis was confirmed by positive chikungunya virus immunoglobulin G and M titers.
- The patient experienced recurrent inflammation despite initial corticosteroid treatment.
Findings:
- This case represents the first reported instance of recurrent chikungunya virus-related uveitis.
- Immunomodulatory therapy achieved sustained control of ocular inflammation in this patient.
- Posterior segment inflammation, including retinal detachments, can be a delayed presentation of chikungunya virus infection.
Implications:
- Chikungunya virus-related uveitis should be considered in patients with acute ocular inflammation, especially those with travel history to endemic areas.
- The increasing incidence of chikungunya fever necessitates heightened awareness among clinicians for its potential ocular complications.
- Recurrent inflammation may require advanced treatment strategies beyond initial corticosteroid therapy.
