[Therapy refractory pain of malignant origin]

In 50 patients with intractable pain due to malignancy an intrathecal application of morphine was performed. The follow-up extended in 28 patients till their death. Overall 46% of the patients had a profit of the therapy for the whole remaining life, 25% at least half of it. The main indication to intrathecal infusion of morphine is in multiloculare and midline pain especially in advanced cancer stage.