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[Therapy refractory pain of malignant origin]
Zentralblatt Fur Neurochirurgie
|January 1, 1989
Summary
Intrathecal morphine application provided significant pain relief for cancer patients. Over 70% experienced benefits, with many finding lasting comfort.
Area of Science:
- Oncology
- Pain Management
- Pharmacology
Context:
- Intractable pain in advanced cancer poses significant challenges.
- Limited efficacy of conventional analgesics necessitates alternative treatments.
- Intrathecal drug delivery offers targeted pain relief.
Purpose:
- To evaluate the efficacy and long-term benefits of intrathecal morphine in patients with malignancy-related intractable pain.
- To identify patient subgroups and pain characteristics that predict successful treatment outcomes.
Summary:
- Fifty patients with intractable cancer pain received intrathecal morphine.
- Follow-up data, including to death, was available for 28 patients.
- 46% reported sustained pain relief throughout their remaining life; 25% experienced relief for at least half their remaining life.
Impact:
- Intrathecal morphine infusion is a viable option for managing severe cancer pain.
- Multilocular and midline pain in advanced stages are key indications.
- This therapy can significantly improve quality of life for palliative care patients.