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Heart transplantation for advanced heart failure due to cardiac sarcoidosis

Efstratios K Theofilogiannakos1, Stephen James Pettit, Azmee Ghazi

  • 1. etheofil@gmail.com.

Sarcoidosis, Vasculitis, and Diffuse Lung Diseases : Official Journal of WASOG
|October 1, 2015
PubMed

Insights

Heart transplantation for cardiac sarcoidosis in carefully selected patients shows excellent outcomes, with no recurrence of disease observed. This study highlights the viability of heart transplant for advanced heart failure due to cardiac sarcoidosis.

Area of Science:

  • Cardiology
  • Immunology
  • Transplantation Medicine

Background:

  • Cardiac sarcoidosis poses a risk for heart transplant recipients due to potential disease recurrence.
  • Extra-cardiac sarcoidosis progression can also impact post-transplant outcomes.

Purpose of the Study:

  • To evaluate the outcomes of heart transplantation in patients with cardiac sarcoidosis.
  • To compare these outcomes with a control group without cardiac sarcoidosis.

Main Methods:

  • Retrospective analysis of heart transplant recipients between 1990 and 2012.
  • Cardiac sarcoidosis diagnosis confirmed by pathological examination of explanted hearts.
  • Comparison of baseline characteristics and clinical outcomes between cardiac sarcoidosis and control groups.

Main Results:

  • Twelve patients with cardiac sarcoidosis underwent heart transplantation.
  • Excellent post-transplant survival rates: 92% at one year and 83% at five years.
  • No cases of recurrent cardiac sarcoidosis or progressive extra-cardiac sarcoidosis were observed during follow-up.

Conclusions:

  • Heart transplantation is a viable option for carefully selected patients with advanced heart failure due to cardiac sarcoidosis.
  • Outcomes are comparable to patients transplanted for other conditions.
  • Physicians should recognize that much of the existing data on cardiac sarcoidosis transplantation involves cases diagnosed post-explantation.
Abstract

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